Oxytocin analogues with amide groups substituted by tetrazole groups in position 4, 5 or 9.
نویسندگان
چکیده
منابع مشابه
Oxytocin analogues with amide groups substituted by tetrazole groups in position 4, 5 or 9.
Eleven oxytocin analogues substituted in position 4, 5 or 9 by tetrazole analogues of amino acids were prepared using solid-phase peptide synthesis method and tested for rat uterotonic in vitro and pressor activities, as well as for their affinity to human oxytocin receptor. The tetrazolic group has been used as a bioisosteric substitution of carboxylic, ester or amide groups in structure-activ...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2007
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2007_3169